Tested on sheep in Switzerland, the surgical elastic "implant device," essentially a wrapping that mimics bone's own sock-like sheath called periosteum, delivered stem cells, growth factors and other natural components of the periosteum to heal a defect that would not heal on its own if left untreated. In experimental groups exhibiting best outcomes, a dense network of new bone filled the defect, from the surgical elastic wrapping on the outside towards the steel intramedullary nail that stabilized the bone on the inside, bridging old with new bone.
Melissa Knothe Tate, a joint professor of biomedical engineering and mechanical & aerospace engineering at Case Western Reserve University; Ulf Knothe, an orthopedic surgeon at the Cleveland Clinic, as well as Hana Chang and Shannon Moore, graduate students in Knothe Tate's lab, report their work in today's issue of PLoS ONE. Surgical Membranes as Directional Delivery Devices to Generate Tissue: Testing in an Ovine Critical Sized Defect Model (PDF)
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