This indicates that N-acetyl can serve as an important bio-marker of OA disease progression. A decrease in the alanine concentration in OA may be attributed to the degradation of the collagen framework with disease progression and eventual loss of the degradation products that are transported from cartilage into the synovial cavity. Shet K, Siddiqui SM, Yoshihara H, Kurhanewicz J, Ries M, Li X. NMR Biomed. 2011 Aug 18. doi: 10.1002/nbm.1769. [Epub ahead of print] PMID: 21850648
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