Injectable calcium sulfate/mineralized collagen-based bone repair materials with regulable self-setting properties.

An injectable and self-setting bone repair materials (nano-hydroxyapatite/collagen/calcium sulfate hemihydrate, nHAC/CSH) was developed in this study. The nano-hydroxyapatite/collagen (nHAC) composite, which is the mineralized fibril by self-assembly of nano-hydrocyapatite and collagen, has the same features as natural bone in both main hierarchical microstructure and composition. It is a bioactive osteoconductor due to its high level of biocompatibility and appropriate degradation rate. However, this material lacks handling characteristics because of its particle or solid-preformed block shape. Herein, calcium sulfate hemihydrate (CSH) was introduced into nHAC to prepare an injectable and self-setting in situ bone repair materials. Chen Z, Liu H, Liu X, Cui FZ. J Biomed Mater Res A. 2011 Sep 20. doi: 10.1002/jbm.a.33212. [Epub ahead of print] PMID: 21936045