There was a monotonic inverse dose-response gradient between serum 25(OH)D and risk of stress fracture. There was double the risk of stress fractures of the tibia and fibula in women with serum 25(OH)D concentration < 20 ng/ml, compared to those with ≥ 40 ng/ml. A target for prevention of stress fractures would be a serum 25(OH)D concentration of > 40 ng/ml, achievable with 4000 IU/day vitamin D(3) supplementation. Burgi AA, Gorham ED, Garland CF, Mohr SB, Garland FC, Zeng K, Thompson K, Lappe JM. J Bone Miner Res. 2011 Jun 22. doi: 10.1002/jbmr.451. [Epub ahead of print] Naval Health Research Center, San Diego, California.
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