Avascular tissues such as a cartilage contains a unique type of cell called as the chondrocyte. We, however have not understood the origin of the chondrocyte population and how this population is maintained in the normal tissue. In spite of being considered to be a simple tissue, scientist had always faced difficulties to engineer this tissue. This is because different structural regions of the articular cartilage were never understood. In addition to this, the limited self-repair potential of cartilage tissue and lack of effective therapeutic options for the treatment of damaged cartilage has remained an unsolved problem. Mathur D, Pereira WC, Anand A. J Cell Biochem. 2011 Sep 16. doi: 10.1002/jcb.23367. [Epub ahead of print] PMID: 21928321
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