Repair of rat calvarial bone defects by controlled release of rhBMP-2 from an injectable bone regeneration composite.

The objective of the present study was to enhance the regeneration ability of an injectable bone regeneration composite (IBRC) by the controlled release of recombinant human bone morphogenetic protein-2 (rhBMP-2)...In vitro and in vivo studies suggested that the present system is a potential bone critical defect repair material for clinical applications.  Tan R, She Z, Wang M, Yu X, Jin H, Feng Q. J Tissue Eng Regen Med. 2011 Sep 13. doi: 10.1002/term.463. [Epub ahead of print] PMID: 21916016