Early effect of hyaluronic acid intra-articular injections on serum and urine biomarkers in patients with knee osteoarthritis: An open-label observational prospective study

The aim of the study was to investigate the effect of hyaluronic acid (HA) intra articular injections (IA) on osteoarthritis (OA) biomarkers in patients with knee OA. Prospective open label study. Fifty-one patients with unilateral symptomatic K-OA received IA injections of 2mL of HA on days (D) 1, 7, 14 and were followed 3 months. Conrozier, T., Balblanc, J.-C., Richette, P., Mulleman, D., Maillet, B., Henrotin, Y., Rannou, F., Piroth, C., Hilliquin, P., Mathieu, P., Walliser-Lohse, A., Rousselot, I., Plattner, V., Maillefert, J.-F., Vignon, E., Chevalier, X. Journal of Orthopaedic Research; Article first published online: 24 OCT 2011 PDF